The murder - and legacy - of a real estate agent in Arkansas is retold through the words of her son.

Outside of Dallas, a killing spree is fueled by rage and revenge.

A nurse disappears in San Antonio without a trace and amid troubling circumstances.

A brutal murder in a Jacksonville suburb leads police to a shocking conclusion decades later.

Decades of terrifying attacks lead police in Buffalo on a desperate search for a killer.

A California mother of two disappears while jogging near her Redding, California, home.

Vanessa Guillen vanished from Fort Hood in Texas in April. After months of searching, the case came to a shocking end last week.

A peaceful afternoon at a popular park in the Cleveland suburbs is shattered when two friends are murdered.

In 1978, a 15-year-old cheerleader, Barbara Nantais, and her boyfriend, Jim Alt, joined another couple for a summer night at a remote beach in San Diego. But a night of teenage fun was cut short when they were brutally attacked, leaving one dead and another in a coma.

Kyron Horman was last seen at Skyline School in Portland, Oregon on June 4, 2010. He was in second grade when he vanished. He's never been found.

Suzanne Morphew went for a bike ride on Mother's Day and didn't return.

Four years after a mother of two is murdered, her killer makes a bold decision.

A toddler in Maine vanishes overnight and no one has any answers.

An Extreme Threat | 49

The Principal's Wife Part 2 | 48

Joe Bryan spent more than three decades behind bars for the murder of his wife. He still says he didn't do it.

Justice for Randisha Love | 46

A young mother and fitness instructor is ambushed in the early morning hours inside a small-town Texas church.

Can hundreds of volunteers come together to help solve a decades-old mystery?

A Tampa, Florida neighborhood is terrorized by a serial killer in 2017.

It was a horrific crime that stunned the city of Austin. Four teenage girls murdered inside a yogurt shop on Dec. 6, 1991.

It's been over three years since Robert Baron vanished from the Pennsylvania pizza restaurant his family has owned since the 1960s.

Six women vanished. Four found dead. Two remain missing.

Helene Pruszynski vanished after riding a bus from downtown Denver to Littleton after work on Jan. 16, 1980. Her body was found the next day. Decades later genetic genealogy might solve this case.

A family in Georgia is still looking for their son after a bizarre series of events in October 2016.