Senate Minority Leader Mitch McConnell is determined to stamp out an isolationist, pro-Trump wing of his party that has pushed back on $40 billion in aid to Ukraine — and U.S. support more broadly. Andrew Desiderio reports.

The Vice President has cast more tie-breaking votes than all but two predecessors. It’s starting to frustrate some staff. Eugene Daniels reports.

Legalizing weed isn’t the top priority for most voters, but Pennsylvania Lt. Gov. John Fetterman — who clinched the Dem nom for Senate — is betting that it could help draw people to the polls. Natalie Fertig reports.

When friends and family got sick last year, people across Ghana scrambled to get shots. But there weren’t enough. Now, many say they don’t want the jab. Local volunteers are struggling to change their minds. Erin Banco reports.

Today, primary voters in North Carolina's 11th Congressional District will decide whether their representative has become more trouble than he's worth. Once a rising conservative star, Cawthorn is now mired in controversy, facing the very real possibility his electoral career might end as quickly as it began. Michael Kruse reports.

A growing number of U.S. lawmakers are pressing the Biden administration to establish a humanitarian corridor in the Black Sea, to help transport millions of tons of grain from Ukraine to the world food supply. But doing so is complicated — and could provoke retaliation from Russia. Meredith Lee reports.

President Joe Biden and Democrats have pushed through billions of dollars in new funding for rural development. But now comes the hard part — working through a federal bureaucracy that makes it almost impossible for local leaders in the smallest, poorest areas to figure out how to get the money. Ximena Bustillo reports on a new system that hopes to solve the problem.

Blue-state governors and lawmakers from California to New York are vowing to turn their states into sanctuaries for people seeking abortions. Plus, the years-long push for over-the-counter birth control is ramping up inside the FDA in the wake of a potential Supreme Court decision rolling back abortion rights. Lauren Gardner reports.

The debate over Bitcoin and other cryptocurrencies took on a new dimension last month when Fidelity Investments, one of the world’s largest asset managers, announced that it would soon allow participants in its 401(k) plans to invest some of their retirement savings in Bitcoin. Last Wednesday, that led Sens. Elizabeth Warren, D-Mass., and Tina Smith, D-Minn., to send Fidelity a letter challenging the decision. Ben Schreckinger reports.

A bitter GOP primary in West Virginia has turned into one of the most hard-fought Republican primaries of the midterms, testing everything from Trump’s influence and the potency of ideological purity to small government to whether a GOP congressman can sell his primary voters on the merits of a bipartisan compromise in a hyper-polarized climate. Ally Mutnick reports.

Last week, speculation spread that the U.S. provided intelligence to Ukraine that helped target Russian generals and Russia’s Moskva warship. Alex Ward explains why these leaks created such a firestorm.

Presenting Playbook Deep Dive: This week on Playbook Deep Dive, POLITICO’s Peter Canellos talks with our own Josh Gerstein, who broke this week’s massive news that the Supreme Court’s conservative majority has drafted an opinion to overturn Roe v. Wade. Peter and Josh nerd out on everything from the history of the court, to potential implications of the draft opinion — both for the country and the judiciary itself.

Clinical trials have long been plagued by inefficiency, lack of diversity and the inability to leverage data. The pandemic increased the need to modernize trials, which pushed many trials to lean on technology to conduct trials remotely. Ben Leonard explains why money is pouring into the space and why many clinical trials are still stuck in the previous century.

According to an initial draft majority opinion written by Justice Samuel Alito circulated inside the court and obtained by POLITICO, the Supreme Court has voted to strike down the landmark Roe v. Wade decision, kicking abortion policy to the states. Michigan Gov. Gretchen Whitmer filed a lawsuit last month challenging her state’s 1931 law banning abortion, which would go into effect when Roe is struck down. Alice Miranda Ollstein reports.

The Biden administration is scrambling to counter China’s new security pact with the Solomon Islands and a possible military base in the South Pacific nation. Phelim Kine reports.

Months before two infants died and another was hospitalized from bacterial infections, a whistleblower alerted senior FDA officials to what he said were "lax practices, including regulatory violations" at an Abbott Nutrition infant formula plant last October. But it was still months before the FDA investigated and formula was recalled. Helena Bottemiller-Evich reports.

Presenting Playbook Deep Dive: The White House Correspondents’ Dinner is back for the first time since 2019. Journalists, A-list celebrities and Washington’s power players will pack the cavernous ballroom at the Washington Hilton. That means brunch is back too. On this week’s episode, Playbook co-author Ryan Lizza gets a tour from Tammy Haddad at the site of her annual garden brunch, one of the most sought after invites of the weekend. Plus, insights from comedian and WHCD alum Elayne Boosler and Ed Solomon of Anthony's Tuxedos in Georgetown.

The FDA may propose a rule banning menthol cigarettes as early as today, a decision 10 years in the making. Katherine Foley reports.

The world’s richest man has a lot of experience getting his way in Washington. But doing it as Twitter's owner may be different. Rebecca Kern reports.

Federal regulators are just beginning to tackle a technical flaw that threatens to hold back the United States’ next giant leap in communications: Many of our radios suck. John Hendel reports.

An alleged human trafficking ring in Georgia highlights many of the loopholes found in the H-2A agricultural visa program, renewing calls for an overhaul. Ximena Bustillo reports.

This week Playbook co-author Ryan Lizza is in Arizona to dig into a few big plotlines ahead of this year’s elections. Trump narrowly lost the state in 2020, Senator Mark Kelly – the Democratic incumbent – is one of the most vulnerable senators up for reelection this year and strategists are already looking at the 2024 Senate election to see who will run against Kyrsten Sinema. On this week’s Playbook Deep Dive Episode, Ryan joins Rep. Ruben Gallego for a long dinner and a few drinks. They discuss Gallego’s fraught history with Sinema, a potential campaign against her in 2024, the political environment in Arizona ahead of midterms and his deployment in the Iraq war.

Russia’s ambassador to the United States can’t get meetings with senior officials at the White House or the State Department. He can’t convince U.S. lawmakers to see him, and it's rare to find an American think tanker who’s willing to admit to having any contact with the envoy. Senior foreign affairs correspondent Nahal Toosi discusses her conversation with Russia’s ambassador to the U.S. and D.C.'s loneliest man, Anatoly Antonov.

We're six and a half months out from the the midterms, and to keep track of the almost 500 seats up for grabs, POLITICO has launched an election forecaster. Steve Shepard, the man behind the tracker, breaks down his 2022 election predictions and which races to keep an eye on.